• Application

Application of MOCs

 

Introduction:

MOCs always contain various carbon-polymetal bonds with mixed π- and σ-type carbon-metal bonding and considerable metal-metal bonding. The characteristic multi-bonding nature enables MOCs to feature unique synergistic mechanisms and optical properties. Based on controllable synthesis and analysis of the well-defined structures, MOCs show promising applications in organometallic catalysis, luminescent materials and bioinorganic chemistry.

  

As a special case of geometry control of MOCs, the arrangement of metal atoms in an asymmetric pattern is crucial for understanding the chirality origin and facilitating the development of new chiral catalysts and chiroptical devices. We utilize chiral polyanionic species as an inner template to control the geometry of metal clusters and achieved a series of chiral clusters in multiple patterns including sigmoidally and reverse-sigmoidally arranged gold clusters, biaryl-centered gold clusters with axial chirality and spirocyclic nonanuclear silver clusters. Based on detailed structural characterizations, the circular dichroism responses and chiroptical photoluminescence are found to be strongly associated with the chiral arrangement of metal atoms.     

 

Inner templated chiral clusters. J. Am. Chem. Soc.2016, 138, 5634; Chem. Sci.2018, 9, 5614; CCS Chem.2020, 2, 555; Angew. Chem. Int. Ed.2021, 60, 1535.

 

The characteristic multi-bonding nature not only enables MOCs to feature excellent stablility towards air and moisture, but also adopt unique synergistic mechanisms in organometallic transformations. We develop a kind of hypercoordinated carbon-centered gold clusters with a characteristic cooperativity in bond dissociation processes to release mutilfold of [AuPPh3]+ ions activated by GSH. The consecutively released Au(I) ions cause a significant pro-oxidant response within cancer cells. As a consequence, accelerated ferroptosis is triggered via such MOC-based prodrug strategy.

 

Schematic of pharmacological mechanisms of hypercarbon-centered gold(I) cluster prodrugs.

 

 

 


  • <a href='http://www.tsinghua.edu.cn/' target='_blank' title='清华大学'>清华大学</a>
  • <a href='https://www.chem.tsinghua.edu.cn/index.htm' target='_blank' title='化学系'>化学系</a>
  • <a href='http://zhaogroup.chem.tsinghua.edu.cn/main.htm' target='_blank' title='The Zhao Group'>The Zhao Group</a>